What is Manganese?

Manganese is an essential trace element; it’s needed for good health but is only required in tiny amounts. The FDA established an adequate intake (AI) of 2.3mg/day for men and 1.8mg/day for females in 2001^[1]. EFSA set a slightly higher AI value of 3mg/day for all adults while for labeling 2mg/day is used^[2]. Manganese deficiency is rare, and the symptoms are not well established^[3]. It’s possible that a lack of manganese causes bone demineralization and skin rashes^[3].

Function

Manganese is involved in the metabolism of food to produce energy as it acts as a cofactor for several enzymes^[4]. It also has pro- and antioxidant activities^[5]. Manganese is one of the required compounds for manganese superoxide dismutase which is a major scavenger of reactive oxygen species in cells^[5].

Manganese toxicity is partly attributable to its prooxidant activity, which can cause oxidative stress that the body can’t cope with^[6].

Toxicity

Most manganese toxicity cases come from inhalation of manganese in industry and mining over months and years^[7]. This is because inhaled manganese can enter the bloodstream and avoid the liver, which would usually cause the excretion of a significant proportion of the manganese^[8].

There is limited evidence that intake of water high in manganese may be associated with neurological symptoms, but this has only occurred in areas where the drinking water was contaminated with manganese^[8]. Plus, manganese in drinking water may be more bioavailable than that in food^[1].

Nutritionally, manganese is one of the least toxic elements because, when excess is consumed, absorption is very low and that which is absorbed is efficiently excreted via bile and the kidneys^[9].

There has never been a reported case of anyone consuming too much manganese from food, and there is no evidence that the consumption of a manganese-rich plant-based diet, as in the case of Huel Powder, results in manganese toxicity^[10]. Part of this could be explained by the presence of antinutrients and other micronutrients, such as iron which affect the bioavailability of manganese^[11]. The only caution is in people who suffer from chronic liver disease who should consult a doctor before consuming Huel Powder.

Manganese in Huel

There is a high level of manganese in Huel, and it’s all naturally occurring mainly from the oats (which are very manganese-rich) and flaxseed. 2,000kcal of Huel Powder provides around 9mg of manganese. A bottle of Huel Ready-to-drink contains 0.5mg of manganese and a Huel Bar provides 0.3mg.

It has been shown that plant-based diets, such as the Ornish diet, can provide on average 11.5mg of manganese per day. This is above the upper limit of 11mg/day set by the US, based purely on the highest levels (10.9mg/day) presented in studies^[1]. The EU has no upper limit due to insufficient evidence^[2]. Yet there is a distinct lack of adverse effects reported as a result of higher levels of consumption^{[10, 12]}.

Therefore, there is no need to be concerned with the high levels of manganese in Huel.

References

1. Institute of Medicine Panel on M. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US)
Copyright 2001 by the National Academy of Sciences. All rights reserved.; 2001.
2. Efsa Panel on Dietetic Products N, et al. Scientific Opinion on Dietary Reference Values for manganese. EFSA Journal. 2013; 11(11):3419.
3. Ziegler TR, et al. Modern nutrition in health and disease. Wolters Kluwer Health Adis: Philadelphia; 2012.
4. NHS. Others: Manganese. Date Accessed: 21/10/19. [Available from: https://www.nhs.uk/conditions/vitamins-and-minerals/others/#manganese]
5. Li L, et al. The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. Oxid Med Cell Longev. 2018; 2018:7580707-.
6. Tuschl K, et al. Manganese and the brain. International review of neurobiology. 2013; 110:277-312.
7. Williams M, et al. Toxicological Profile for Manganese. Agency for Toxic Substances and Disease Registry (US): Atlanta (GA); 2012.
8. O'Neal SL, et al. Manganese Toxicity Upon Overexposure: a Decade in Review. Current environmental health reports. 2015; 2(3):315-28.
9. Greger JL. Dietary standards for manganese: overlap between nutritional and toxicological studies. J Nutr. 1998; 128(2 Suppl):368s-71s.
10. Institue LP. Oregon State University. Manganese. Date Accessed: [Available from: 21/10/19]
11. Kies C. Manganese Bioavailability Overview. Nutritional Bioavailability of Manganese. ACS Symposium Series. 354: American Chemical Society; 1987. p. 1-8.
12. LeMoon T. Manganese Levels in Plant-based Diets May Exceed U.S. Dietary Recommendations-an Examination of the Ornish and DASH Diets (P24-011-19). Curr Dev Nutr. 2019; 3(Supplement_1).